MS-226: Nineteenth Century Pennsylvania Trade Cards

This collection contains 80 nineteenth century trade cards from businesses primarily in Philadelphia (six are from other Pennsylvania location) as well as two decorative images and one three- dimensional square map of Central Europe in German. The cards advertise for a variety of goods and services, including clothing, groceries, beauty and health products, printers, plumbers, jewelers, florists, and more. Many of the cards depict cherubic children, fashionable men and women, prudent consumers using the products advertised, fine art, and include poems, promotions, and manufacturer guarantees. These cards may be of interest to anyone studying methods of advertisement and marketing, graphic design, business history, pharmaceutical history, consumer habits, 19th century fashion and customs, as well as other aspects of Pennsylvania or American social and cultural history. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1194/thumbnail.jp

MS – 198: Letters of Leonard G. Roberts

The letters from Leonard (Mike) Roberts to Geraldine Smith Roberts are very much the correspondence of a young, homesick husband in love. The first series of the collection includes five letters from Mike dated 1937 and two notes presumed to be circa the same time, marking the progress of their teenage courtship. The collection resumes in 1944 when Roberts begins his military service. Drafted late in the war, Roberts was not posted overseas until January, 1945. The letters detail his deployment and military life with a hiatus between February 3rd April 6th as Roberts is taken prisoner by the Germans. His letters continue after his release, detailing his mental, physical, and spiritual condition. With a keen awareness of the censors, Mike reports as much as he is able to on the conditions in camp, traveling through France, his desire for the Germans to surrender and the war to end, his treatment and daily life in a military hospital, and events back home in Coffeyville, Kansas. One letter in the collection, dated February 19th, 1945 was sent from Geraldine to Mike. It is as heartsick as Mike’s letters are to her, full of news from home and fantasies about their life after the war. Series 5 contains 3 newspaper clippings that offer information on Mike’s liberation from prison camp and post-war career. The Roberts’ letters offer an intimate look at one of many long distance relationships between deployed men and their wives during the Second World War. This collection has research potential for anyone interested in correspondence, the daily duties and lives of soldiers in WWII France, German prison camps, or recovery in a military hospital. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website https://www.gettysburg.edu/special-collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1207/thumbnail.jp

Airborne observations of the Eyjafjalla volcano ash cloud over Europe during air space closure in April and May 2010

© Author(s) 2011. This work is distributed under the Creative Commons Attribution 3.0 LicenseAirborne lidar and in-situ measurements of aerosols and trace gases were performed in volcanic ash plumes over Europe between Southern Germany and Iceland with the Falcon aircraft during the eruption period of the Eyjafjalla1 volcano between 19 April and 18 May 2010. Flight planning and measurement analyses were supported by a refined Meteosat ash product and trajectory model analysis. The volcanic ash plume was observed with lidar directly over the volcano and up to a distance of 2700 km downwind, and up to 120 h plume ages. Aged ash layers were between a few 100 m to 3 km deep, occurred between 1 and 7 km altitude, and were typically 100 to 300 km wide. Particles collected by impactors had diameters up to 20 μm diameter, with size and age dependent composition. Ash mass concentrations were derived from optical particle spectrometers for a particle density of 2.6 g cm-3 and various values of the refractive index (RI, real part: 1.59; 3 values for the imaginary part: 0, 0.004 and 0.008). The mass concentrations, effective diameters and related optical properties were compared with ground-based lidar observations. Theoretical considerations of particle sedimentation constrain the particle diameters to those obtained for the lower RI values. The ash mass concentration results have an uncertainty of a factor of two. The maximum ash mass concentration encountered during the 17 flights with 34 ash plume penetrations was below 1 mg m-3. The Falcon flew in ash clouds up to about 0.8 mg m-3 for a few minutes and in an ash cloud with approximately 0.2 mg -3 mean-concentration for about one hour without engine damage. The ash plumes were rather dry and correlated with considerable CO and SO2 increases and O3 decreases. To first order, ash concentration and SO2 mixing ratio in the plumes decreased by a factor of two within less than a day. In fresh plumes, the SO2 and CO concentration increases were correlated with the ash mass concentration. The ash plumes were often visible slantwise as faint dark layers, even for concentrations below 0.1 mg m-3. The large abundance of volatile Aitken mode particles suggests previous nucleation of sulfuric acid droplets. The effective diameters range between 0.2 and 3 μm with considerable surface and volume contributions from the Aitken and coarse mode aerosol, respectively. The distal ash mass flux on 2 May was of the order of 500 (240-1600) kgs -1. The volcano induced about 10 (2.5-50) Tg of distal ash mass and about 3 (0.6-23) Tg of SO2 during the whole eruption period. The results of the Falcon flights were used to support the responsible agencies in their decisions concerning air traffic in the presence of volcanic ash.Peer reviewe

A qualitative investigation of lived experiences of long-term health condition management with people who are food insecure.

Background: As more people are living with one or more chronic health conditions, supporting patients to become activated, self-managers of their conditions has become a key health policy focus both in the UK and internationally. There is also growing evidence in the UK that those with long term health conditions have an increased risk of being food insecure. While international evidence indicates that food insecurity adversely affects individual's health condition management capability, little is known about how those so affected manage their condition(s) in this context. An investigation of lived experience of health condition management was undertaken with food insecure people living in north east Scotland. The study aimed to explore the challenges facing food insecure people in terms of, i. their self-care condition management practices, and ii. disclosing and discussing the experience of managing their condition with a health care professional, and iii. Notions of the support they might wish to receive from them. Methods: Twenty in-depth interviews were conducted with individuals attending a food bank and food pantry in north east Scotland. Interview audio recordings were fully transcribed and thematically analysed. Results: Individuals reporting multiple physical and mental health conditions, took part in the study. Four main themes were identified i.e.: 1. food practices, trade-offs and compromises, that relate to economic constraints and lack of choice; 2. illness experiences and food as they relate to physical and mental ill-health; 3. (in) visibility of participants' economic vulnerability within health care consultations; and 4. perceptions and expectations of the health care system. Conclusions: This study, the first of its kind in the UK, indicated that participants' health condition management aspirations were undermined by the experience of food insecurity, and that their health care consultations in were, on the whole, devoid of discussions of those challenges. As such, the study indicated practical and ethical implications for health care policy, practice and research associated with the risk of intervention-generated health inequalities that were suggested by this study. Better understanding is needed about the impact of household food insecurity on existing ill health, wellbeing and health care use across the UK

An NF-κB and Slug Regulatory Loop Active in Early Vertebrate Mesoderm

BACKGROUND: In both Drosophila and the mouse, the zinc finger transcription factor Snail is required for mesoderm formation; its vertebrate paralog Slug (Snai2) appears to be required for neural crest formation in the chick and the clawed frog Xenopus laevis. Both Slug and Snail act to induce epithelial to mesenchymal transition (EMT) and to suppress apoptosis. METHODOLOGY & PRINCIPLE FINDINGS: Morpholino-based loss of function studies indicate that Slug is required for the normal expression of both mesodermal and neural crest markers in X. laevis. Both phenotypes are rescued by injection of RNA encoding the anti-apoptotic protein Bcl-xL; Bcl-xL's effects are dependent upon IκB kinase-mediated activation of the bipartite transcription factor NF-κB. NF-κB, in turn, directly up-regulates levels of Slug and Snail RNAs. Slug indirectly up-regulates levels of RNAs encoding the NF-κB subunit proteins RelA, Rel2, and Rel3, and directly down-regulates levels of the pro-apopotic Caspase-9 RNA. CONCLUSIONS/SIGNIFICANCE: These studies reveal a Slug/Snail–NF-κB regulatory circuit, analogous to that present in the early Drosophila embryo, active during mesodermal formation in Xenopus. This is a regulatory interaction of significance both in development and in the course of inflammatory and metastatic disease

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Verschiedene Deutungen des gleichen Krieg: Wie Jünger und Remarque den Zweck ihrer Grabenerfahrungen ausgraben

Two Perspectives on one Great War: Remarque and Jünger This work looks at two prominent texts in the German war novel canon, All Quiet on the Western Front by Erich Maria Remarque and Storm of Steel by Ernst Jünger. These very different books represent the attempts of two Great War soldiers to recall their trench war experience and assign meaning to the slaughter and destruction of the first truly modern war. During the Weimar Republic (1919-1933), All Quiet and Storm of Steel contributed to the two dominant cultural narratives regarding the war, one which rejected war as dehumanizing and immoral and another which saw Germany\u27s demise as an opportunity for a new beginning. The literary style and themes conveyed by Remarque and Jünger provide different conceptions of the nature of war and man\u27s role in it. Verschiedene Deutungen des gleichen Krieges: Remarque und Jünger Diese Arbeit befasst sich mit zwei prominenten Texten im Kanon des deutschen Kriegsromans, Im Westen nichts Neues von Erich Maria Remarque und In Stahlgewittern von Ernst Jünger. Diese sehr unterschiedlichen Bücher stellen die Versuche der Autoren dar, ihre eigene Erfahrung des Ersten Weltkriegs zu erzählen und dem Schlachten und der Zerstörung des ersten modernen Krieges eine Bedeutung zu geben. In der politisch instabilen Weimarer Republik wurden Im Westen und In Stahlgewittern zu den beiden dominierenden kulturellen Narrativen über den 1. Weltkrieg. Eine dieser Perspektiven lehnte den Krieg als entmenschlichend und unmoralisch ab, der andere sah den Untergang Deutschlands als eine Chance für einen Neuanfang. Meine Arbeit untersucht, wie Remarques und Jüngers  literarische Stile und Themen unterschiedliche Vorstellungen von des Art und dem Zweck des Kriegs und der Rolle des Menschen in ihm vermitteln